Thrown out of her New York City apartment, Natalia, a 25-year-old hot mess, relies on the kindness of friends and strangers. Seemingly unaware of the havoc she wreaks, she skips from one place to another, including her best friend's, where she crashes a holiday meal and seduces the best friend's socially inept brother. With a menagerie of New York characters, set against the backdrop of a homeless shelter, a religious household, and the cacophonous streets of New York, Soft in the Head is a look at how easy it is to lose one's head in the big city.